Troponin bound to heparin triggers decrease calculated troponin plasma concentration in comparison with serum.[76] Other sources of interference that will impact the assay detection method and cause false-detrimental troponin values incorporate ascorbic acid in immunoenzymometric assays using alkaline phosphatase, biotin in assays utilizing a biotinylated antibody, streptokinase inside the presence of streptavidin, and high titers of antibodies to ruthenium or streptavidin in cTnT assays.
The non-ST segment elevation myocardial infarction (NSTEMI) can be an injury to your cardiac muscle that results in an elevated troponin but lacks the ECG alterations that outline an ST-section elevation myocardial infarction.
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Effects might be confounded if there is lousy preanalytical handling of troponin specimens, including incomplete sample mixing at enough time of specimen selection, insufficient sample centrifugation and separation of crimson cells from serum or plasma, existence of fibrin due to incomplete serum separation, and so forth.
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